Annulus fibrosus cell sheets limit disc degeneration in a rat annulus fibrosus injury model
نویسندگان
چکیده
منابع مشابه
Theoretical and uniaxial experimental evaluation of human annulus fibrosus degeneration.
The highly organized structure and composition of the annulus fibrosus provides the tissue with mechanical behaviors that include anisotropy and nonlinearity. Mathematical models are necessary to interpret and elucidate the meaning of directly measured mechanical properties and to understand the structure-function relationships of the tissue components, namely, the fibers and extrafibrillar mat...
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The annulus fibrosus (AF) of the intervertebral disc experiences cyclic tensile loading in vivo at various states of mechanical equilibrium. Disc degeneration is associated with alterations in the biochemical composition of the AF including decreased water content, decreased proteoglycan concentration, and increased collagen deposition that affect mechanical function of the AF in compression an...
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Intervertebral disc (IVD) degeneration is the major cause of lower back pain, while the currently available treatments are symptomatic rather than curative. Tissue engineering is a powerful therapeutic strategy that can restore the normal biomechanical motion of the human spine. The ability of a biphasic elastic scaffold to structurally and elastically simulate the annulus fibrosus (AF) tissue ...
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C ALCIUM deposition in diseased heart valves may be demonstrated frequently in necropsy studies, but these deposits are usually overlooked clinicaIIy unless the heart is carefuIly examined roentgenographically. Sosman1 discusses in detail a simple method of demonstrating the presence of calcific deposits within the heart by x-ray. He suggests a small fluoroscopic aperture and a screen of high i...
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INTRODUCTION Programmed cell death of intervertebral disc (IVD) cells plays an important role in IVD degeneration, but the role of autophagy, a closely related cell death event, in IVD cells has not been documented. The current study was designed to investigate the effect of interleukin (IL)-1β on the occurrence of autophagy of rat annulus fibrosus (AF) cells and the interrelationship between a...
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ژورنال
عنوان ژورنال: JOR SPINE
سال: 2019
ISSN: 2572-1143,2572-1143
DOI: 10.1002/jsp2.1050